NanoBrook 90Plus Particle Size Analyzer Utilized in Anti-Cancer Drug Carrier Research

Nov 7, 2019
Applications: BiopharmaDrug DeliveryEncapsulation
Instruments: NanoBrook Series
image of syringe and vials

Science Direct featured the study “Thermosensitive Polymer-Conjugated Albumin Nanosphere As Thermal Targeting Anti Cancer Drug Carrier” which investigated a strategy to allow anti-cancer drug association with intelligent drug carriers. Zheyu Shen and his colleagues utilized Brookhaven’s NanoBrook 90Plus Particle Size Analyzer to facilitate dynamic light scattering (DLS) to measure particle size and distribution used for the purpose of this study.

The findings of the study resulted in a thermal targeting anti-cancer drug carrier, Poly (N-isopropylacrylamide-co-acrylamide-co-allylamine) (PNIPAM-AAmAA)-conjugated albumin nanospheres (PAN ), which was done by conjugating PNIPAM-AAm-AA on the surface of albumin nanosphere (AN). The experiment was able to illustrate that fast drug release from PAN in a certain temperature indicated an increase of drug release rate at the target sites, like cancer cells or tissues, after intravenous injection. The results from this study showed that PAN could be used as a thermal targeting anti-cancer drug carrier and could eliminate undesirable side effects generated by free drugs or cancerous chemotherapy.

Research into effective anti-cancer drugs is rapidly expanding. To ensure meticulous and effective research in biomedicine, experts should rely on instruments that are operative, up-to-date and accessible. Brookhaven Instruments offers products that are state-of-the-art and are of the highest quality. Among the products offered, is the NanoBrook 90Plus Particle Size Analyzer for fast, routine and sub micron measurements.