NanoBrook 90Plus Particle Size Analyzer Helps in Dual-Ligand Liposome Research

Nov 7, 2019
Applications: BiopharmaDrug DeliveryEncapsulation
Instruments: NanoBrook Series
image of liposome

Science Direct featured a study entitled “A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers.” Justin M. Saul and his colleagues studied a new approach that would enhance targeting selectivity of drug-loaded nanocarriers.

The researchers, to facilitate this study, constructed and designed dual-ligand carriers. This was done through a rigorous process which involves coupling single-ligand folate or mAB225 liposomal carriers. For consistency and accuracy, a Brookhaven NanoBrook 90Plus Particle Size Analyzer was used to determine liposome size through dynamic light scattering analysis. The dual-ligand liposomes simultaneously target multiple receptors in order to reduce unintended uptake of toxicity in off-target cells. Through this study, the researchers were able to demonstrate that nanocarriers can be designed to achieve toxicity only when all targeted receptors are available, providing an approach to improve selectivity over current single-ligand approaches.

Particle characterization through dynamic light scattering is a technique used by experts to characterize particles as they study biomedical developments. To achieve accuracy with their studies, scientists only use high-quality particle size analyzers. Brookhaven Instrument provides high quality particle size analyzers including the NanoBrook 90Plus Particle Size Analyzer, a fast, flexible and reliable instrument for particle characterization.