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When Molecular Weight is Important

Molecular weight and size are two key properties of all macromolecules including biologically important and synthetic polymers. Performance and processability are directly related to these parameters. Light scattering is capable of absolute measurements in either batch or flow mode. For distribution information, couple a GPC/SEC instrument to a light scattering detector.

For GPC measurements or for simple batch-mode measurements, select the BI-MwA, a seven-angle, flow-through instrument. Augment it with the BI-DNDC differential refractometer for use as either an RI concentration detector or to determine the differential refractive index increment.

For small macromolecules, the new 90PDP Debye plot option on the 90Plus, 90Plus Zeta, 90Plus PALS, 173, 173Plus or Omni allows molecular weight determination. Consider this option if you need to measure particle size and/or zeta potential as well as molecular weight. Don’t forget the BI-APD high sensitivity detector for molecules smaller than about 200 kDa.

For research involving both static and dynamic light scattering, consider the BI-200SM goniometer and the TurboCorr digital autocorrelator. In batch mode, this combination offers the same information as the BI-MwA; yet, it adds dynamic light scattering for hydrodynamic sizing and scattering factors to study shape. These are the tools of choice for basic polymer research.

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