Application Library

Nov 8, 2019

Zeta Potential and Membrane Fouling; Research at Yale

The Deparment of Chemical and Environmental Engineering, Yale University, USA, carries out advanced research into water purification including studies of natural and engineered aquatic systems. After moving to Yale from UCLA two years ago, the deparment’s Llewellyn West Jones, Professor of Environmental Engineering, Menachem Elimelech, needed a more up-to-date machine to continue his research. Both […]

Applications: ColloidsZeta
Instruments: NanoBrook Series
Zeta Potential Measurements
Nov 8, 2019

Use of Zeta Potential Measurements to Characterize Good and Bad Inks

Zeta Potential of Printing Inks Offers Insights into Performance Inks for high-quality applications are frequently applied using a process by which a series of rollers acquire ink selectively according to a pattern formed on their surfaces and then transfer this ink to the printable substrate. This process is controlled by a combination of mechanically and […]

Applications: ColloidsFormulationsZeta
Instruments: NanoBrook Series
Nov 8, 2019

Colloidal Stability in Aqueous Suspensions

Why too much dispersant causes problems. Abstract Zeta potential in aqueous suspensions is a function of two variables: charge at the shear plane and free salt ion concentration. [Free here means not attached to the particle surface.] If a dispersant is added to increase the surface charge density (increase stability) and it’s too concentrated, the […]

Applications: ColloidsFormulations
Instruments: NanoBrook Series
Nov 8, 2019

BASF chooses Brookhaven again for chemicals research

BASF Agro Research, which develops chemicals for use in agriculture, has purchased a NanoBrook ZetaPALS from Brookhaven Instruments, based on Phase Analysis Light Scattering (PALS), for the determination of zeta potential of colloidal suspensions. Zeta potential is a useful indicator of a formulation’s stability. The new instrument has a particle sizing option based on DLS […]

Applications: Zeta
Instruments: NanoBrook Series
Characterization of Nanoparticle
Nov 8, 2019

New Analysis of Red Blood Cells (RBC) using the ZetaPALS

By Bruce B. Weiner Ph.D. Introduction: Zeta potential is a useful property to know for colloids, nanoparticles, and proteins. It is a substitute for the otherwise hard to measure surface charge. The zeta potential is not equal to the surface potential but rather it is the electrostatic potential difference between a rotationally averaged point at the […]

Applications: BiopharmaDiagnosticZeta
Instruments: NanoBrook Series
Carbonic_Anhydrase_MW
Nov 8, 2019

Molecular Weight Determination of Carbonic Anhydrase with the BI-MwA

by: John McConville, Ph.D. Size-exclusion chromatography (SEC/GPC) has been a useful technique for the determination of molecular weights of proteins. However, its usefulness is limited by the requirement for calibration of the SEC/GPC columns with standards comprising proteins of known molecular weight but which may not be of the same chemistry as the unknown protein. […]

Applications: BiopharmaEnzymesMolecular Weight
Instruments: BI-MwA
Image of Nanoparticles
Nov 8, 2019

How Many Au Nanoparticles Does It Take to Circle the Earth?

Abstract Gold nanoparticles are used in a variety of applications, many pharmaceutical. The average size and the distribution play a crucial role in determining how well they work in a particular application. While TEM can show the shape of nanoparticles, it is not ideal for the statistical task of averaging the size and producing a […]

Applications: SizingTheory
Instruments: NanoBrook Series
Nov 8, 2019

BSA Monomer-Dimer Elucidation with the BI-MwA

Aggregation kills. Aggregated therapeutic proteins can provoke immune response and have reduced therapeutic effect. This has led to regulatory and industrial interest in identifying aggregates for elimination. Size-exclusion chromatography (SEC/GPC) has been a useful technique for the determination of molecular weights of proteins. However, its usefulness is limited by the requirement for calibration of the […]

Applications: BiopharmaChromatographyMolecular Weight
Instruments: BI-MwA
Analysis of Virus Particles in Media by Dynamic Light Scattering
Nov 8, 2019

Analysis of Virus Particles in Media by Dynamic Light Scattering

Introduction Traditional visual methods of observing virus particles in solution give a snapshot of a very small sampling volume, while the technique of particle analysis using dynamic light scattering yields an ensemble average of particles present in the solutions. Virus particles incubated in the laboratory present a challenge, as they must be grown within cells […]

Applications: BiopharmaColloids
Instruments: NanoBrook Series
Nov 8, 2019

Absolute Size Exclusion Chromatography of BSA

Abstract We present results from Bovine Serum Albumin (BSA) measured in an analytical size exclusion chromatography (SEC) system including the Brookhaven BI-MwA static light scattering system. BSA is used ubiquitously as a test protein for concentration and for system calibration and testing. Typical results are presented. Introduction The extraction of insulin from blood plasma was […]

Applications: BiopharmaChromatographyMolecular Weight
Instruments: BI-MwA
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