Application Library

Brookhaven’s NanoBrook 90Plus Particle Size Analyzer Aids in Enhancing Intracellular Delivery of Therapeutic Nucleic Acids

A research on biomaterials entitled, “Degradable, Ph-Sensitive, Membrane-Destabilizing, Comb-Like Polymers For Intracellular Delivery Of Nucleic Acids” was featured in Science Direct. The study discussed the synthesis, characterization and membrane-destabilizing activity of a new series of degradable, pH-sensitive, comb-like polymers that could enhance the intracellular delivery of therapeutic nucleic acids. To facilitate this study, “smart” particles […]

Applications: Drug Delivery
Instruments: NanoBrook Series

Brookhaven Instruments’ New Dielectric Constant Meter

Brookhaven Instruments’ BI-870 Dielectric Constant Meter is a fast and easy-to-use tool for measuring the dielectric constant of liquids. This rugged, compact meter solves the problems associated with measuring mixed liquids and provides the user with precise indication of a suspension’s stability. The BI-870 Dielectric Constant Meter is equipped with a durable, handheld probe made […]

Applications: Self-assembled
Instruments: BI-870

Gene Delivery Research at CalTech

For the past four years, researchers in the Department of Chemical Engineering at the California Institute of Technology have been using a Brookhaven NanoBrook ZetaPALS instrument for their studies on non-viral gene delivery. Professor Mark Davis, Executive Officer of Chemical Engineering, explained: “We need an instrument that can determine the size and zeta potential of […]

Applications: BiopharmaSizingZeta
Instruments: NanoBrook Series

MIT Chooses Brookhaven Instruments Again For Particle Sizing

A research group in the Chemical Engineering Department at the Massachusetts Institute of Technology (MIT) in the USA has recently chosen the NanoBrook ZetaPALS Zeta Potential Analyzer from Brookhaven Instruments to replace an older Brookhaven Instruments particle sizing instrument. The lab studies problems associated with the controlled release of pharmaceuticals, and uses the ZetaPALS analyzer […]

Applications: Self-assembled
Instruments: NanoBrook Series

Brookhaven Instruments autotitrator, the BI-ZTU

The BI-ZTU is Brookhaven Instruments’ easy-to-use autotitrator which provides research and industrial laboratories with a tool to study the effect of pH or additive concentration on zeta potential (surface charge at the shear plane). This accessory for Brookhaven Instruments’ NanoBrook ZetaPlus or ZetaPALS zeta potential analyzers is an excellent choice for automatically determining the isoelectric point of […]

Applications: TitrationsZeta
Instruments: NanoBrook SeriesBI-ZTU

Guide to Making Useful Measurements of Monoclonal Antibodies (mAbs) with Dynamic Light Scattering

Summary Dynamic light scattering (DLS) is a powerful technique that is amenable to measurement of biological samples, particularly proteins and biopolymers. One of the fastest growing classes of pharmaceutically active biologics are antibodies. These highly versatile proteins are used as the major functional element in immunoassays and other rapid diagnostics, in vaccine production, and as […]

Applications: BiopharmaDLSProteins
Instruments: NanoBrook SeriesBI-200SM

Brookhaven Instruments Efficient in Hollow Nanosphere Research

Science Direct presented a study entitled, “Self-Assembly Of B-Cyclodextrin And Pluronic Into Hollow Nanospheres In Aqueous Solution” which investigated self-assembly of b-cyclodextrin (b-CD) and tri-block pluronic (PEG–PPG–PEG) in an aqueous solution. The researchers, Jie Qin and his colleagues, used Brookhaven Instruments to ensure accuracy as they experimented with nanomaterials to facilitate this research. The study […]

Applications: ColloidsNanoParticles
Instruments: BI-200SM

BI-MwA Shines New Light on Polymers

Polymers are never as simple as one would like them to be. Naturally occurring polymers vary in structure depending upon their biological source, while the properties of synthetic polymers depend upon the precise reaction conditions and mix of co-polymers. Dissecting out subtle difference in polymer structures often begins with the estimation of molecular weights based […]

Applications: Polymers
Instruments: BI-MwA
image of Zeta PALS

ZetaPALS Brochure

Zeta Potential & Particle Size Analyzer For Measurements In: Solvents High Salt Oily or viscous media Near the isoelectric point 1,000x more sensitive than other techniques ZetaPALS: A Whole New Concept For measurements of low mobility, the unique, Brookhaven Instruments ZetaPALS is the answer. There is nothing else like it. With concepts developed at Bristol […]

Applications: Zeta
Instruments: NanoBrook Series