Application Library

BSA Monomer-Dimer Elucidation with the BI-MwA

Aggregation kills. Aggregated therapeutic proteins can provoke immune response and have reduced therapeutic effect. This has led to regulatory and industrial interest in identifying aggregates for elimination. Size-exclusion chromatography (SEC/GPC) has been a useful technique for the determination of molecular weights of proteins. However, its usefulness is limited by the requirement for calibration of the […]

Applications: BiopharmaChromatographyMolecular Weight
Instruments: BI-MwA

Research on TB Vaccine breakthrough used Brookhaven’s NanoBrook ZetaPlus

BMC Immunology, an open access journal, published a study entitled “Evaluation Of Specific Humoral Immune Response And Cross Reactivity Against Mycobacterium Tuberculosis Antigens Induced In Mice Immunized With Liposomes Composed Of Total Lipids Extracted From Mycobacterium Smegmatis”. Maria De los Angeles Garcia and her colleagues aimed to demonstrate the potential of a liposome formulation composed […]

Applications: BiopharmaZeta
Instruments: NanoBrook Series

Nano-Composites at University of Sussex

The Brookhaven Instruments BI-DCP Disc Centrifuge is providing to be crucial piece of equipment for a group of polymer researchers led by, Dr. Steve Armes. The team, based at the University of Sussex in the UK, is developing new polymer nanocomposite particles for a range of important uses including better ways to diagnose deadly illnesses […]

Applications: NanoParticles
Instruments: BI-DCP

Brookhaven’s BI-200SM Effective in DNA Compaction Research featured in Oxford University Press

Oxford University Press’ Nucleic Acids Research featured a study entitled “Packaging Of DNA By Shell Crosslinked Nanoparticles”. The researchers of this study, Thurmond and his colleagues, made use of Brookhaven’s BI-200SM Goniometer in conducting dynamic light scattering (DLS) experiments that allowed a thorough observation of DNA compaction by shell-crosslinked Knedel-like (SCKs) nanoparticles. The researchers demonstrated […]

Applications: DNASelf-assembled
Instruments: BI-200SM

Analysis of Virus Particles in Media by Dynamic Light Scattering

Introduction Traditional visual methods of observing virus particles in solution give a snapshot of a very small sampling volume, while the technique of particle analysis using dynamic light scattering yields an ensemble average of particles present in the solutions. Virus particles incubated in the laboratory present a challenge, as they must be grown within cells […]

Applications: BiopharmaColloids
Instruments: NanoBrook Series

Zeta Potential and Membrane Fouling; Research at Yale

The Deparment of Chemical and Environmental Engineering, Yale University, USA, carries out advanced research into water purification including studies of natural and engineered aquatic systems. After moving to Yale from UCLA two years ago, the deparment’s Llewellyn West Jones, Professor of Environmental Engineering, Menachem Elimelech, needed a more up-to-date machine to continue his research. Both […]

Applications: ColloidsZeta
Instruments: NanoBrook Series

BI-DCP Helps in Studying Styrene/Butyl Acrylate Miniemulsion-based PSAs

A study by University of Ottawa’s Department of Chemical Engineering entitled, “The Effect of Particle Size And Composition on The Performance of Styrene/Butyl Acrylate Miniemulsion-Based PSAs”, discussed how the control over particle sizes afforded by miniemulsions could enable us to affect the properties of pressure-sensitive adhesives (PSAs) in a controlled manner. In this particular study, […]

Applications: Polymers
Instruments: BI-DCP

Brookhaven’s NanoBrook 90Plus Particle Size Analyzer Used in Designing an Oral Drug Delivery System for Fluconazole

The International Journal of Pharmacy and Pharmaceutical Sciences presented a study entitled, “A Bio-Based Approach In Designing An Oral Drug Delivery System For Fluconazole”. In this study, M. Joyce Nirmala and her team applied the dynamic light scattering technique with Brookhaven’s NanoBrook 90Plus Particle Size Analyzer to characterize the tiny droplets resulting from the size […]

Applications: BiopharmaDrug Delivery
Instruments: NanoBrook Series

21 CFR Part 11 compliant software from Brookhaven Instruments

Brookhaven Instruments Corporation offers 21 CFR Part 11 compliant software for its NanoBrook particle sizer, in line with the FDA’s rules governing electronic signatures and records. The BI-PSD21 runs as a closed system via a specific user interface and can export data to third party applications. The software comes with full information on validation and […]

Applications: 21 CFR
Instruments: NanoBrook Series

Chromatography and Latex Particles; Dionex Corp.

Dionex Corporation in California, USA, has recently replaced an old BI-90 Particle Size Analyzer from Brookhaven Instruments with a new 90Plus with the ZetaPALS option. After 18 years continuous service from the old instruments, Charanjit Saini, a graduate polymer chemist in the Polymer Chemistry Department, explained why she opted for Brookhaven Instruments again, “We have […]

Applications: Colloids
Instruments: NanoBrook Series