Application Library

BSA Monomer-Dimer Elucidation with the BI-MwA

Aggregation kills. Aggregated therapeutic proteins can provoke immune response and have reduced therapeutic effect. This has led to regulatory and industrial interest in identifying aggregates for elimination. Size-exclusion chromatography (SEC/GPC) has been a useful technique for the determination of molecular weights of proteins. However, its usefulness is limited by the requirement for calibration of the […]

Applications: BiopharmaChromatographyMolecular Weight
Instruments: BI-MwA

Hong Kong University of Science and Technology Uses Brookhaven Instruments

The Hong Kong University of Science and Technology physics department presented a study on the “Influence of liquid Phase on Nanoparticle-based giant electrorheological fluid.” The researchers, Xiuqing Gong and his colleagues, demonstrated how the chemical structures of silicone oils interacting with solid nanoparticles significantly influenced the giant electrorheological (GER) effect. In order to prepare and […]

Applications: Gels
Instruments: NanoBrook Series

Guide to Making Useful Measurements of Monoclonal Antibodies (mAbs) with Dynamic Light Scattering

Summary Dynamic light scattering (DLS) is a powerful technique that is amenable to measurement of biological samples, particularly proteins and biopolymers. One of the fastest growing classes of pharmaceutically active biologics are antibodies. These highly versatile proteins are used as the major functional element in immunoassays and other rapid diagnostics, in vaccine production, and as […]

Applications: BiopharmaDLSProteins
Instruments: NanoBrook SeriesBI-200SM

Rohm and Haas Uses Brookhaven Instruments for QC

Leading manufacturer of speciality chemicals, Rohm and Haas, has recently bought a Brookhaven Instruments 90Plus Particle Size Analyzer to increase the throughput of work carried out by the Quality Control department at the Jarrow Plant, Tyne and Wear. Geoff Lowther, Quality Controller, said, “We have a long standing relationship with Brookhaven and used its instruments […]

Applications: Quality Control
Instruments: NanoBrook Series

Brookhaven’s BI-200SM Used in Investigative Study on Cyclosporin A

The Journal of Controlled Release presented a study entitled “Investigation Of The Factors Influencing The Release Rates Of Cyclosporin A-Loaded Micro- And Nanoparticles Prepared By High-Pressure Homogenizer”. The study, conducted by Woo-kyoung Lee and his colleagues, used Brookhaven’s BI-200SM to aid them in preparing cyclosporin A (CyA)–loaded particles varying in size, polymer composition and additive […]

Applications: BiopharmaEnzymes
Instruments: BI-200SM

Probing Sub-microscopic Particles

Colloids are complex physical systems, but understanding their properties is important in the development of of products in a variety of sectors. The Bristol Colloid Center (BCC) at the UK’s University of Bristol has been using two different instruments from Brookhaven in their research into colloidal systems Use of Brookhaven’s Bl-200SM dynamic and static light […]

Applications: Colloids
Instruments: BI-200SM

Colloidal Polymers

New and exciting applications are tantalizing goals for many researchers and, with uses ranging from new sensitive pregnancy testing kits to military camouflage, polymer chemistry has an intriguing future. The Sussex Polymer Group is based in the School of Chemistry, Physics and Environmental Science at the University of Sussex. It has two full-time faculty members […]

Applications: ColloidsPolymers
Instruments: BI-DCP

Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties

The journal of Nanobiotechnology recently published a study entitled “Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties,” that cited Brookhaven BI-200SM Goniometer in the analysis of assemblies’ hydrodynamic diameter and stability. This study conducted by Goeffrey Bothun aimed to achieve nanoparticle encapsulation by trapping particles within the hydrophobic […]

Applications: Emulsions
Instruments: BI-200SM

Determining Molecular Weights

Breaking new ground in polymer science A long-standing collaboration between Brookhaven Instruments Corporation and the Physics department at Tulane University in New Orleans, USA, has broken new ground in the understanding of polymer characterization. This has resulted in the development of the Brookhaven BI-MwA, a molecular weight analyzer for online monitoring of polymerization reactions. Professor […]

Applications: Polymers
Instruments: BI-MwA

Particle and Polymer Characterization

The University of Manchester’s School of Pharmacy has been using a Brookhaven Instruments TurboCorr Digital Autocorrelator to help improve research procedures and the instrument has been proven particularly well matched to the detection of aggregates measuring only a few nanometers in size. The TurboCorr was chosen over competitive systems because it offered more advanced features. […]

Applications: ColloidsSizing
Instruments: TurboCorr