Application Library

A Horizontal View of Light Scattering for Characterizing Proteins, Polymers and Nanoparticles

By Bruce B. Weiner Ph.D. Introduction The large number of properties that can be determined using various forms of light scat­tering is impressive: molecular weight, radius of gyration, and second virial coefficient using static light scattering (SLS) on synthetic polymers and natural biopolymers like proteins; diffusion coefficient, hydrodynamic radius, and size distribution using dynamic light […]

Applications: BiopharmaDLSNanoParticlesPolymersSLS
Instruments: NanoBrook SeriesBI-200SM
Dynamic Light Scattering Banner

What is Dynamic Light Scattering?

Dynamic Light Scattering (DLS) is a measurement technique that provides a fast and simple method for submicron and nanoparticle sizing.

Applications: DLSTheory
Instruments: NanoBrook SeriesBI-200SM

Brookhaven Instruments Goniometer Helps Solve “Blue Waters” Mystery

A BI-200SM Research Goniometer with BI-9000AT Autocorrelator from Brookhaven Instruments has recently helped researchers at the Brookhaven National Laboratory* in New York solve the enigma of why aqueous molybdenum solutions are blue. Dr. Tianbo Liu in the Department of Physics explained, “Molybdenum and oxygen can combine to form a wide variety of structures and some […]

Applications: DLSPolymers
Instruments: BI-200SM

Brookhaven’s BI-200SM Helps Investigate an Amphiphilic Siloxane Graft Copolymer in Water

Yining Lin and Paschalis Alexandridis authored a research study entitled “Self-Assembly Of An Amphiphilic Siloxane Graft Copolymer In Water” which was featured in the Journal of Physical Chemistry. The researchers probed the self-assembly behavior of silicone containing surfactants in water with a variety of experimental techniques. To ensure that data gathered was accurate, the researchers […]

Applications: Polymers
Instruments: BI-200SM

NanoBrook 90Plus Particle Size Analyzer Aids in Determining the Impact of nZVI Stability on Mobility in Porous Media

The Journal of Contaminant Hydrology featured a study entitled “The Impact of nZVI Stability on Mobility in Porous Media”. The study, through column experiments and numerical modeling, aimed to predict the impact of polymer-stabilized nZVI aggregation and settling on nZVI transport over a range of pore water velocities that may be used in the field. […]

Applications: Colloids
Instruments: NanoBrook Series

NanoBrook ZetaPlus Zeta Potential Analyzer Effective in Characterization of Nanoparticle Uptake by Endothelial Cells

The International Journal of Pharmaceuticals presented a study entitled, “Characterization Of Nanoparticle Uptake By Endothelial Cells” by Jasmine Davda and Vinod Labhasetwar. It characterized the uptake of biodegradable nanoparticles by endothelial cells in cell culture through photon correlation spectroscopy (PCS). The researchers used a Brookhaven NanoBrook ZetaPlus zeta potential analyzer to obtain the diameter size […]

Applications: NanoParticlesZeta
Instruments: NanoBrook Series

Absolute Size Exclusion Chromatography of BSA

Abstract We present results from Bovine Serum Albumin (BSA) measured in an analytical size exclusion chromatography (SEC) system including the Brookhaven BI-MwA static light scattering system. BSA is used ubiquitously as a test protein for concentration and for system calibration and testing. Typical results are presented. Introduction The extraction of insulin from blood plasma was […]

Applications: BiopharmaChromatographyMolecular Weight
Instruments: BI-MwA

Molecular and Engineering Thermodynamics; University of Delaware

The Center for Molecular and Engineering Thermodynamics (CMET), part of the University of Delaware’s Department of Chemical Engineering, is a focal point for experimental and theoretical research into techniques that are increasingly being used to tackle contemporary issues such as environmental problems, the purification of pharmaceuticals and new separations technologies. The Center is investigating methods […]

Applications: Complex FluidsSizingZeta
Instruments: NanoBrook Series

ZetaPALS System Boosts Energy Transduction Project

Scientists in the Department of Biochemistry at the University of the Pacific have been using a Brookhaven ZetaPALS System to investigate the mechanisms behind biological energy transduction. Professor of Biochemistry and Director of Biomedical Research, Stefan Highsmith, explained: “We are studying the electrical properties of contractile proteins, like actin, myosin, tubulin and members of the […]

Applications: Zeta
Instruments: NanoBrook Series

Researchers Study Nanoparticles Using Brookhaven Instruments

The Journal of Electrical Engineering featured a study entitled “Determination of Particle Shape and Size Distribution of Model Types of Nanomaterials” conducted by Edita Bretšnajdrová, Ladislav Svoboda and Jiří Zelenka. Brookhaven’s NanoBrook 90Plus Particle Size Analyzer and XDC were both used in this study as to determine the parameters in preparing various nanomaterials used in […]

Applications: BiopharmaFormulationsNanoParticles
Instruments: NanoBrook SeriesBI-XDC