Comparing the Effects of Two Different Lipophilic Surfactants on the Zeta Potential of CBD Nanoemulsions

Comparing the Effects of Two Different Lipophilic Surfactants on the Zeta Potential of CBD Nanoemulsions Cannabidiol, CBD, is a non-psychoactive chemical compound obtained from Cannabis sativa. CBD has many benefits including anti-inflammatory properties and neuropathic pain relief, which may be preferred over other pain-relieving methods due to its non-addictive characteristics. CBD is lipophilic oil and […]

Applications: EmulsionsFormulationsZeta
Instruments: NanoBrook Series

Posted on: Mar 24, 2023

Dynamic Light Scattering (DLS) & CBD Nanoemulsions

Summary Cannabidiol, CBD, is a non-psychoactive chemical compound obtained from Cannabis sativa, more specifically the hemp plant. CBD has many benefits including anti-inflammatory properties and neuropathic pain relief, which may be preferred over other pain-relieving methods due to its non-addictive characteristics. Furthermore, CBD can be helpful in managing anxiety and mood disorders, improving sleep, and […]

Applications: DLSEmulsionsFormulationsSample Prep
Instruments: NanoBrook Series

Posted on: Mar 8, 2023

Zeta Potential Performance Verification

Summary The purpose of this guide is to demonstrate the proper method for preparing a zeta potential validation sample used for checking the performance of the NanoBrook ZetaPlus, ZetaPALS, 90PlusPALS, and Omni instrumentation. The BI-ZR5 validation material is a dark blue, inorganic powder that is insoluble in water. It has a mean particle size of […]

Applications: Sample PrepZeta
Instruments: NanoBrook Series

Posted on: May 13, 2022

What is a Discrete Particle Size Distribution?

In the previous entry in this series of papers on particle size and size distribution, the main features of the differential and cumulative size distribution functions were defined and discussed using continuous distributions. Continuous distributions can be measured approximately in fractionation experiments† where, for example, data is taken every second as fractionated slices of the […]

Applications: DLSParticle Sizing

Posted on: Aug 11, 2021

What is a Continuous Particle Size Distribution?

Particle size distribution data can be presented numerically (tabular format) or graphically. When presented graphically, there are two types: differential and cumulative. They are related. If one differentiates the cumulative distribution curve, the differential distribution is obtained. If one integrates the differential distribution curve, the cumulative distribution is obtained. Differential Distribution The differential distribution shows […]

Applications: Particle Sizing

Posted on: Jun 2, 2021

Using Static Light Scattering to Measure Polymer Molecular Weights

What is Static Light Scattering? Static light scattering (SLS) is a technique that leverages high precision photon counting to measure size, molecular weight, and other structural parameters. Common samples include synthetic polymers, nanoparticles, biomolecules, and other macromolecules. SLS makes extensive use of extrapolation, typically with respect to scattering angle, concentration, or in the case of […]

Applications: DLSMolecular WeightSLS

Posted on: May 20, 2021

DLS FAQ: Data Portability & Archiving

In order for DLS data to be relatable to a physically meaningful parameter, frequently size, it is necessary to know a number of other parameters describing either the solvent, measurement conditions, or the configuration of a given hardware system. Brookhaven fully supports export of raw data, specially DLS autocorrelation functions, for fitting using more advanced algorithms. […]

Applications: DLS
Instruments: BI-200SMNanoBrook SeriesParticle ExplorerParticle Solutions

Posted on: Apr 29, 2021

Phosphatidylcholine and Stearylamine molecules

Characterizing Liposomes with DLS and Zeta Potential: Tools for Drug Delivery

Summary Liposomes are a common system used to encapsulate and deliver bioactive cargo molecules. In contrast to simple emulsions (oil-in-water or water-in-oil), these lipid vesicles are composed of well-defined bilayer structures and have aqueous interiors. These bilayers encircle the molecule of interest, often proteins or oligonucleotides such as DNA or RNA. These vesicle structures are inherently […]

Applications: BiopharmaDrug DeliveryParticle SizingZeta
Instruments: NanoBrook Series

Posted on: Mar 26, 2021

migrating bands in Brookhaven's DCP centrifuge

A Useful Tool for Measuring Carbon Black: Disc Centrifuge Photosedimentometry (DCP)

Summary An industrial carbon black sample was used for the purpose of demonstrating the efficacy of the Brookhaven Instruments DCP. Due to the intrinsically differential nature of the results, it is possible to identify the existence of multiple species even from raw, uncorrected results. The basis of this technique is sedimentation, meaning that larger particles […]

Applications: Carbon BlackParticle Sizing
Instruments: BI-DCP

Posted on: Feb 16, 2021

disc centrifuge sedimentometry diagram illustration

Principles of Operation for Disc Centrifuges

Both disc centrifuges separate particles according to size and density, making these methods ideal for high-resolution particle sizing. The Disc Centrifuge Photosedimentometer (DCP) uses visible light for detection, whereas the X-Ray Disc Centrifuge (XDC) uses a compact X-Ray source. Despite different sources of contrast, the two techniques both operate on similar principles. In both cases, […]