Application Library

CBD Nanoemulsions
Mar 24, 2023

Comparing the Effects of Two Different Lipophilic Surfactants on the Zeta Potential of CBD Nanoemulsions

Cannabidiol, CBD, is a non-psychoactive chemical compound obtained from Cannabis sativa. CBD has many benefits including anti-inflammatory properties and neuropathic pain relief, which may be preferred over other pain-relieving methods due to its non-addictive characteristics. CBD is lipophilic oil and has poor bioavailability due to low solubility in water. A new method for CBD delivery […]

Applications: EmulsionsFormulationsZeta
Instruments: NanoBrook Series
CBD Nanoemulsions
Mar 8, 2023

Dynamic Light Scattering (DLS) & CBD Nanoemulsions

Summary Cannabidiol, CBD, is a non-psychoactive chemical compound obtained from Cannabis sativa, more specifically the hemp plant. CBD has many benefits including anti-inflammatory properties and neuropathic pain relief, which may be preferred over other pain-relieving methods due to its non-addictive characteristics. Furthermore, CBD can be helpful in managing anxiety and mood disorders, improving sleep, and […]

Applications: DLSEmulsionsFormulationsSample Prep
Instruments: NanoBrook Series
May 13, 2022

Zeta Potential Performance Verification

Summary The purpose of this guide is to demonstrate the proper method for preparing a zeta potential validation sample used for checking the performance of the NanoBrook ZetaPlus, ZetaPALS, 90PlusPALS, and Omni instrumentation. The BI-ZR5 validation material is a dark blue, inorganic powder that is insoluble in water. It has a mean particle size of […]

Applications: Sample PrepZeta
Instruments: NanoBrook Series
cumulative undersize discrete distribution
Aug 11, 2021

What is a Discrete Particle Size Distribution?

In the previous entry in this series of papers on particle size and size distribution, the main features of the differential and cumulative size distribution functions were defined and discussed using continuous distributions. Continuous distributions can be measured approximately in fractionation experiments† where, for example, data is taken every second as fractionated slices of the […]

Applications: DLSParticle Sizing
differential size distribution
Jun 2, 2021

What is a Continuous Particle Size Distribution?

Particle size distribution data can be presented numerically (tabular format) or graphically. When presented graphically, there are two types: differential and cumulative. They are related. If one differentiates the cumulative distribution curve, the differential distribution is obtained. If one integrates the differential distribution curve, the cumulative distribution is obtained. Differential Distribution The differential distribution shows […]

Applications: Particle Sizing
sls zimm plot
May 20, 2021

Using Static Light Scattering to Measure Polymer Molecular Weights

What is Static Light Scattering? Static light scattering (SLS) is a technique that leverages high precision photon counting to measure size, molecular weight, and other structural parameters. Common samples include synthetic polymers, nanoparticles, biomolecules, and other macromolecules. SLS makes extensive use of extrapolation, typically with respect to scattering angle, concentration, or in the case of […]

Applications: DLSMolecular WeightSLS
Particle Solutions archive file
Apr 29, 2021

DLS FAQ: Data Portability & Archiving

In order for DLS data to be relatable to a physically meaningful parameter, frequently size, it is necessary to know a number of other parameters describing either the solvent, measurement conditions, or the configuration of a given hardware system. Brookhaven fully supports export of raw data, specially DLS autocorrelation functions, for fitting using more advanced algorithms. […]

Applications: DLS
Instruments: BI-200SMNanoBrook SeriesParticle ExplorerParticle Solutions
Phosphatidylcholine and Stearylamine molecules
Mar 26, 2021

Characterizing Liposomes with DLS and Zeta Potential: Tools for Drug Delivery

Summary Liposomes are a common system used to encapsulate and deliver bioactive cargo molecules. In contrast to simple emulsions (oil-in-water or water-in-oil), these lipid vesicles are composed of well-defined bilayer structures and have aqueous interiors. These bilayers encircle the molecule of interest, often proteins or oligonucleotides such as DNA or RNA. These vesicle structures are inherently […]

Applications: BiopharmaDrug DeliveryParticle SizingZeta
Instruments: NanoBrook Series
migrating bands in Brookhaven's DCP centrifuge
Feb 16, 2021

A Useful Tool for Measuring Carbon Black

Disc Centrifuge Photosedimentometry (DCP) Summary An industrial carbon black sample was used for the purpose of demonstrating the efficacy of the Brookhaven Instruments DCP. Due to the intrinsically differential nature of the results, it is possible to identify the existence of multiple species even from raw, uncorrected results. The basis of this technique is sedimentation, […]

Applications: Carbon BlackParticle Sizing
Instruments: BI-DCP
disc centrifuge sedimentometry diagram illustration
Feb 16, 2021

Principles of Operation for Disc Centrifuges

A disc centrifuge separates particles according to size and density, making it an ideal method for high-resolution particle sizing. The Disc Centrifuge Photosedimentometer (DCP) uses visible light for the detection of the particles. The planning of a disc centrifuge experiment involves selecting an appropriate spin fluid and disc speed to achieve the desired level of […]

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