Brookhaven’s BI-200SM Effective in DNA Compaction Research featured in Oxford University Press

Nov 7, 2019
Applications: DNASelf-assembled
Instruments: BI-200SM
image of DNA

Oxford University Press’ Nucleic Acids Research featured a study entitled “Packaging Of DNA By Shell Crosslinked Nanoparticles”. The researchers of this study, Thurmond and his colleagues, made use of Brookhaven’s BI-200SM Goniometer in conducting dynamic light scattering (DLS) experiments that allowed a thorough observation of DNA compaction by shell-crosslinked Knedel-like (SCKs) nanoparticles.

The researchers demonstrated compaction of DNA with nanoscale biomimetic constructs and SCK nanoparticles, which are robust synthetic analogs of globular proteins. DLS measurements obtained from Brookhaven’s BI-200SM confirmed that the SCK/DNA aggregates formed while in a solution, provided that the interactions between DNA and SCK produced complexes that are multimeric in SCK. The results of the study were able to show that synthetic functional structures can effectively compact DNA and protect it from enzymatic digestion. Additionally, an approach using Biomimicry to design important synthetic or natural materials for the development of successful gene therapy solutions was also presented.

DLS analysis is a technique often used by scientists and researchers for conducting studies in the fields of biology and biotechnology. Through this technique, results are easily obtained from experiments involving nanoparticles. Scientists and researchers only rely on equipment that ensures reliability and accuracy. Brookhaven Instruments features only the most reliable, accurate and technologically competitive analytical equipment in the market. Among the equipment offered is Brookhaven’s BI-200SM which is adept for both Static Light Scattering and Dynamic Light Scattering techniques.