Brookhaven NanoBrook 90Plus Particle Size Analyzer Aids in Nanoparticle Research for Lung Clearance Rates and Translocation

Nov 7, 2019
Applications: BiopharmaHealthNanoParticles
Instruments: NanoBrook Series
image of lungs

A research by Aamir Abid and his colleagues was featured in Particle and Fibre Toxicology entitled, “Novel Lanthanide-Labeled Metal Oxide Nanoparticles Improve The Measurement Of In Vivo Clearance And Translocation”. The study’s goal was to provide a proof-of-concept for the usefulness of nanoparticles to study lung clearance rates and translocation over longer time-scales. Additionally, it aimed to define the methodology for use of these particles in vivo.

A Brookhaven NanoBrook 90Plus Particle Size Analyzer was used to obtain the number weighted (NW) particle size distribution of the nanoparticles used in this study. The zeta potential of the nanoparticles was then measured via light scattering using Brookhaven’s ZetaPlus. With these nanoparticles, the researchers conducted a series of experiments and were able to detect particles remaining in the lung. They also found a significant amount in the feces samples, suggesting fast clearance mechanisms. Through this study, a system to link dose with biological effect was developed. The particles and approaches described in this study also paved the way for developmental studies on lung biology and inhalation exposures.