Science Direct featured a study that examined the aqueous solubilization of Paclitaxel (PTX) in polymer micelles without using any organic solvents usually required for solubilization in polymer micelles. In this study, entitled “A New Hydrotropic Block Copolymer Micelle System For Aqueous Solubilization Of Paclitaxel”, Kang Moo Huh and his colleagues used a BI-200SM Goniometer to determine dynamic light scattering measurements in forming a pH-dependent micelle.
Through the obtained measurements of pH-dependent micelles, the researchers were able to deduce how the pH level affected the aqueous solubility of PTX. Through this finding, the researchers were able to provide a simpler and easier process of PTX formulation without using organic solvent.
This research provides significant information to the water-solubility of therapeutic drugs during formulation for clinical applications, especially in the development of patient friendly formulas. Paclitaxel, a potent anti-cancer drug, is poorly soluble in water, but through this study and with the help of highly efficient Brookhaven Instruments, it was concluded that PTX’s aqueous solubility could be enhanced with the addition of hydrotropic polymers.
The BI-200SM Goniometer is included in Brookhaven Instruments’ line of top quality, state-of-the-art particle size analyzers. The BI-200SM particle size analyzer allows academic institutions and scholars to obtain data for both Static Light Scattering (SLS) and Dynamic Light Scattering (DLS) techniques.
Instruments: