Light Scattering

Features at a glance

• Extreme reproducibility and reliability
• Up to 768 unattended measurements
• Super low sample volume, 2 µL fresh sample, recoverable
• Standard well plate and vials, mix & match
• Complete biocompatible parts
• Sampling sequence by column or row, auto-prep system compatible
• Integrated, independent temperature control for sample tray and cell
• High throughput, 36 samples / hr.

High-throughput Characterization of Proteins, Peptides and Other Particles Used in Aggregation or Formulation Studies

Particle sizing, by dynamic light scattering, is an invaluable technique for formulation characterization and aggregation studies. It works with unmodified, undiluted samples. It offers exquisite sensitivity to enable detection of even the initiation of aggregation, information that is invaluable to the pharmaceutical scientist concerned about loss of activity or immunogenicity in pharmaceutical preparations, or to the pharmacologist screening for potentially therapeutic inhibitors of aggregation. Until recently, however, the power of this technology has not been capable of meeting industrial throughput requirements.

Now Brookhaven Instruments, the company that has pioneered fundamental innovation in light scattering for thirty years, is proud to announce the release of the BioDLS, an instrument that combines the power of dynamic light scattering with modern automatic liquid handling to yield unsurpassed convenience and accuracy in formulation characterization and aggregation assays.

The BioDLS allows automatic particle sizing using industry–standard well plates. The precision controlled sample transfer mechanism allows the user to select any arbitrary well to initiate the experiment, as little as 2 uL sample volume is required for a measurement, and allows recovery of the transferred sample. Samples can be stored in up to two 384-well plates in an independently temperature-controlled compartment, and up to 768 samples can be transferred automatically to the flow cell without user intervention. The measuring cell has independent temperature control, allowing thermal studies related to stability and aggregation on individual samples. These features, coupled with the high-throughput fluid handling, allow the sensitivity, precision, and accuracy required for biotechnology and pharmaceutical research on proteins, peptides, viruses and antibodies.

Nanoparticles in flow cell

Benefits

• Automate experiments and obtain results rapidly
• Conserves precious samples
• Perform experiments with no consumable costs
• Detect aggregation at its onset
• Analyze samples without dilution
• Use without chemical modification of substrates
• Minimize toxic chemical exposure with robotics
• Interpret data using established theory

A policy of continued improvement may lead to specification changes.